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. 2016 Nov 1;7:409. doi: 10.3389/fphar.2016.00409

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Copyright © 2016 Suhaimi, Ab Mutalib and Jamal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular pathways currently being targeted in the treatment of endometrial cancer (EC) and the potential actionable genes in EC identified via Next Generation Sequencing (NGS). Red star depicted genes with clinically cancer-relevant drug interactions as defined by DGIdb (Wagner et al., 2016). (A) PI(3)K, MAPK, p53 and apoptosis pathway involving PIK3CA, PTEN, PPP2R1A, KRAS, P53, and BCL2, (B) cell cycle pathway involving FBXW7 and CCNE1 as well as (C) DNA replication pathway in eukaryote which involves POLE (DNA polymerase 𝜀). Figures were adapted from Kanehisa et al. (2016) and Seshagiri (2013). Adapted by permission from Macmillan Publishers Ltd: [NATURE GENETICS] (Seshagiri), copyright (2013).