Table 1.
Correlation between SEMA3F expression and clinicopathologic factors of patients with osteosarcoma
| Variables | SEMA3F expression (N) | ||||
|---|---|---|---|---|---|
|
| |||||
| Total (N = 112) | Positive (76) | Negative (36) | X2 | P-values | |
| Gender | |||||
| Male | 67 (59.8%) | 42 | 25 | 2.044 | 0.215 |
| Female | 45 (40.2%) | 34 | 11 | ||
| Age | |||||
| ≤20 | 74 (66.1%) | 53 | 21 | 1.417 | 0.287 |
| ≥20 | 38 (33.9%) | 23 | 15 | ||
| Tumor Location | |||||
| Femur | 39 (34.8%) | 25 | 14 | 2.960 | 0.565 |
| Tibia | 28 (25.0%) | 17 | 11 | ||
| Humerus | 17 (15.2%) | 8 | 9 | ||
| Fibula | 15 (13.4%) | 7 | 8 | ||
| Others | 13 (11.6%) | 9 | 4 | ||
| Histological classification | |||||
| Osteoblastic | 67 (59.8%) | 36 | 31 | 3.598 | 0.165 |
| Chondroblastic | 36 (32.1%) | 13 | 23 | ||
| Others | 9 (8.1%) | 3 | 6 | ||
| Metastasis | |||||
| Yes | 64 (57.1%) | 25 | 39 | 3.258 | 0.071 |
| No | 48 (42.9%) | 27 | 21 | ||
| Histological grade | |||||
| I | 27 (24.1%) | 14 | 13 | 4.811 | 0.090 |
| II | 53 (47.3%) | 37 | 16 | ||
| III | 32 (28.6%) | 25 | 7 | ||
| Enneking staging | |||||
| I | 28 (25.0%) | 12 | 16 | 14.312 | 0.003 |
| II A | 46 (41.1%) | 31 | 15 | ||
| II B | 31 (27.7%) | 27 | 4 | ||
| III | 7 (6.2%) | 6 | 1 | ||
Abbreviation: SEMA3F, Semaphorin-3F.