Figure 5.

IL-22 protected HUVECs from glucose-induced injury. Cells were treated with glucose (30 mM) for 12 h, followed by incubation with different concentrations of IL-22 for 24 h. The apoptotic rate was quantified by flow cytometry. Cell viability was analyzed using the CCK-8 assay and the results were compared with those obtained for the control group. Data shown represent mean ± SEM of three independent experiments. ^&& P < 0.01 versus control group; ^# P < 0.05; ^## P < 0.01 versus glucose-treated group; ^### P < 0.0001 versus glucose-treated group.