Table 1.
Hemodynamic parameters in the isolated perfused rat hearts subjected to ischemia and reperfusion (I/R) (mean ± SD, n = 5).
| Variable | Baseline | Ischemia | Reperfusion | ||
|---|---|---|---|---|---|
| 30 min | 5 min | 10 min | 120 min | ||
| LVDP (% of baseline ) | |||||
| C I/R | 100 ± 0 | 59 ± 13 | 63 ± 13 | 65 ± 14 | 58 ± 4 |
| DM I/R | 100 ± 0 | 33 ± 7∗∗ | 42 ± 12∗ | 48 ± 5∗∗ | 32 ± 5∗∗ |
| DM + EtOH I/R | 100 ± 0 | 59 ± 15## | 93 ± 12∗∗## | 90 ± 7∗∗## | 58 ± 13## |
| DM + EtOH + CYA I/R | 100 ± 0 | 36 ± 7∗∗∧∧ | 44 ± 8∗∗∧∧ | 44 ± 8∗∗∧∧ | 35 ± 9∗∗∧∧ |
| DM + EtOH + Atr I/R | 100 ± 0 | 38 ± 8∗∗∧ | 48 ± 8∗∧∧ | 47 ± 8∗∗∧∧ | 30 ± 4∗∗∧∧ |
| DM + EtOH + Wor I/R | 100 ± 0 | 39 ± 6∗∗∧∧ | 47 ± 8∗∧∧ | 44 ± 7∗∗∧∧ | 32 ± 3∗∗∧∧ |
| LVEDP (% of baseline) | |||||
| C I/R | 100 ± 0 | 101 ± 1 | 116 ± 2 | 120 ± 10 | 177 ± 11 |
| DM I/R | 100 ± 0 | 151 ± 15∗∗ | 177 ± 14∗∗ | 159 ± 9∗∗ | 262 ± 27∗∗ |
| DM + EtOH I/R | 100 ± 0 | 104 ± 7## | 143 ± 6∗∗## | 141 ± 8∗∗## | 182 ± 14## |
| DM + EtOH + CYA I/R | 100 ± 0 | 155 ± 11∗∗∧∧ | 182 ± 11∗∗∧∧ | 160 ± 12∗∗∧∧ | 254 ± 20∗∗∧∧ |
| DM + EtOH + Atr I/R | 100 ± 0 | 147 ± 20∗∗∧∧ | 166 ± 3∗∗∧∧ | 166 ± 5∗∗∧∧ | 251 ± 16∗∗∧∧ |
| DM + EtOH + Wor I/R | 100 ± 0 | 168 ± 19∗∗∧∧ | 176 ± 7∗∗∧∧ | 170 ± 11∗∗∧∧ | 281 ± 45∗∗∧∧ |
| +dp/dt max (% of baseline) | |||||
| C I/R | 100 ± 0 | 64 ± 10 | 80 ± 15 | 78 ± 12 | 55 ± 8 |
| DM I/R | 100 ± 0 | 48 ± 8 | 43 ± 9∗∗ | 46 ± 5∗∗ | 34 ± 6∗∗ |
| DM + EtOH I/R | 100 ± 0 | 60 ± 14 | 91 ± 17## | 91 ± 19## | 62 ± 11## |
| DM + EtOH + CYA I/R | 100 ± 0 | 47 ± 7 | 46 ± 6∗∗∧∧ | 47 ± 6∗∗∧∧ | 32 ± 7∗∗∧∧ |
| DM + EtOH + Atr I/R | 100 ± 0 | 48 ± 6 | 45 ± 2∗∗∧∧ | 47 ± 4∗∗∧∧ | 34 ± 7∗∗∧∧ |
| DM + EtOH + Wor I/R | 100 ± 0 | 49 ± 9 | 43 ± 6∗∗∧∧ | 44 ± 4∗∗∧∧ | 33 ± 5∗∗∧∧ |
| −dp/dt max (% of baseline) | |||||
| C I/R | 100 ± 0 | 59 ± 13 | 59 ± 10 | 59 ± 1 | 41 ± 5 |
| DM I/R | 100 ± 0 | 42 ± 9∗∗ | 42 ± 6∗∗ | 46 ± 9∗∗ | 31 ± 4∗∗ |
| DM + EtOH I/R | 100 ± 0 | 62 ± 5## | 85 ± 10∗∗## | 84 ± 12∗∗## | 48 ± 6∗## |
| DM + EtOH + CYA I/R | 100 ± 0 | 45 ± 4∗∧∧ | 46 ± 7∗∧∧ | 44 ± 4∗∗∧∧ | 35 ± 4∗∧∧ |
| DM + EtOH + Atr I/R | 100 ± 0 | 43 ± 5∗∗∧∧ | 49 ± 5∗∧∧ | 45 ± 4∗∗∧ | 33 ± 4∗∗∧∧ |
| DM + EtOH + Wor I/R | 100 ± 0 | 46 ± 4∗∧ | 44 ± 5∗∗∧∧ | 43 ± 4∗∗∧∧ | 30 ± 5∗∗∧∧ |
| RPP (% of baseline) | |||||
| C I/R | 100 ± 0 | 59 ± 6 | 62 ± 17 | 62 ± 8 | 33 ± 3 |
| DM I/R | 100 ± 0 | 26 ± 7∗∗ | 32 ± 8∗∗ | 28 ± 7∗∗ | 18 ± 4∗∗ |
| DM + EtOH I/R | 100 ± 0 | 55 ± 13## | 76 ± 7∗## | 79 ± 19∗## | 37 ± 6## |
| DM + EtOH + CYA I/R | 100 ± 0 | 29 ± 5∗∗∧∧ | 28 ± 5∗∗∧∧ | 25 ± 6∗∗∧∧ | 15 ± 5∗∗∧∧ |
| DM + EtOH + Atr I/R | 100 ± 0 | 28 ± 4∗∗∧∧ | 34 ± 6∗∗∧∧ | 31 ± 6∗∗∧∧ | 16 ± 4∗∗∧∧ |
| DM + EtOH + Wor I/R | 100 ± 0 | 32 ± 8∗∗∧∧ | 30 ± 3∗∗∧∧ | 25 ± 4∗∗∧∧ | 18 ± 2∗∗∧∧ |
∗ p < 0.05, ∗∗ p < 0.01 versus C I/R; ## p < 0.01 versus DM I/R; ∧ p < 0.05, ∧∧ p < 0.01 versus DM + EtOH I/R.