Table 2.
Genotypic effects of the exonic variants SNPs in RUNX1, DYRK1A, and KCNJ15 on the pig RBC, MCV, and MCH levels in the pigs
| Single effect | Genotype | RBC1 | p-value | % Var | MCV | p-value | % Var | MCH | p-value | % Var |
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||||
| ADD (SE)2 | ADD (SE) | ADD (SE) | ||||||||
| RUNX1-SNP1 | CC | 7.89 (0.155) | 0.3796 | 53.57 (0.411) a | 6.1×10−5 | 2.65 | 16.85 (0.161) a | 0.0016 | 1.72 | |
| (C1331G)3 | CG | 7.73 (0.099) | −0.008(0.068)NS | 52.86 (0.261) b | 0.79(0.179)*** | 16.68 (0.103) a | 0.25(0.070)*** | |||
| GG | 7.82 (0.088) | 52.03 (0.232) c | 16.40 (0.092) b | |||||||
| DYRK1A-SNP1 | AA | 7.73 (0.093) | 0.1909 | 53.11 (0.243) a | 9.8×10−9 | 4.90 | 16.70 (0.096) a | 2.9×10−5 | 2.81 | |
| (A2989G) | AG | 7.79 (0.088) | −0.09(0.056)NS | 52.13 (0.229) b | 0.89(0.146)‡ | 16.47 (0.091) b | 0.26(0.057)*** | |||
| GG | 7.96 (0.130) | 51.43 (0.337) c | 16.14 (0.134) c | |||||||
| DYRK1A-SNP3 | CC | 7.16 (0.280) a | 0.0057 | 1.43 | 53.61 (0.761) | 0.1295 | 16.82 (0.296) | 0.2651 | ||
| (C5070A) | CA | 7.60 (0.112) a | −0.28(0.090)** | 52.66 (0.302) | 0.46(0.243)NS | 16.62 (0.118) | 0.15(0.094)NS | |||
| AA | 7.86 (0.085) b | 52.29 (0.230) | 16.48 (0.090) | |||||||
| KCNJ15-SNP3 | TT | 7.52 (0.123) a | 0.0386 | 0.94 | 53.59 (0.536) a | 0.0023 | 1.71 | 16.92 (0.213) a | 0.0130 | 1.22 |
| (T1029C) | TC | 7.68 (0.067) a | −0.18(0.070)* | 52.82 (0.253) a | 0.63(0.181)** | 16.63 (0.101) a | 0.21(0.072)** | |||
| CC | 7.86 (0.044) b | 52.22 (0.222) b | 16.44 (0.089) b | |||||||
| KCNJ15-SNP5 | AA | 7.75 (0.090) | 0.5602 | 52.84 (0.235) a | 1.2×10−5 | 3.03 | 16.66 (0.093) a | 0.0003 | 2.18 | |
| (A1232G) | AG | 7.84 (0.094) | −0.07(0.070)NS | 52.03 (0.248) b | 0.88(0.186)*** | 16.39 (0.098) b | 0.29(0.073)*** | |||
| GG | 7.84 (0.196) | 50.81 (0.515) c | 16.01 (0.204) b |
SNP, single-nucleotide polymorphism; RUNX1, runt-related transcription factor 1; DYRK1A, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; KCNJ15, potassium inwardly-rectifying channel, subfamily J, member 15; RBC, red blood cell; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; ADD, additive model; SE, standard error; NS, not significant, KNP, Korean native pigs.
Least squares means and standard error of the traits.
Additive effect and standard error. A positive value means the Korean native pig allele has an increase effect on a trait, and a negative value indicates that the Landrace allele has an increase effect on a trait.
Boldfaced alleles denote that inherited from the KNP.
Least squares means with different superscripts in the same row differ significantly at p<0.05.
p<0.05.
p<0.01.
p<0.001.