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Increased inflammatory response in p53-null mice (scheme of p53-mediated regulation of inflammation). p53 acts at least in two stages of inflammation being a general inhibitor of NF-κB-dependent transcription and a positive regulator of neutrophil clearance by macrophages. Lack of p53 results in overreaction to proinflammatory stimuli (lipopolysaccharide [LPS]) and hypersensitivity of p53-null mice (death). wt, wild type. (From Komarova et al. 2005; with permission, from the authors.)
