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. 2016 Oct 25;17(Suppl 8):737. doi: 10.1186/s12864-016-3070-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Diagram showing the response of K. pneumoniae Kp13 to PB and PB with acid pH. High polymyxin B concentration (left side) and high polymyxin B concentration with acid pH (right side). The mechanisms involved in Kp13’s response in both culture conditions are described in this manuscript. These mechanisms were ranging from LPS modification, capsule and adhesion production, metabolic shift aerobic to fermentation, efflux pump and beta-lactamases overexpression, regulation of iron metabolism (ferritin-like protein), acid response and DNA damage repair