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. 2016 Oct 1;30(19):2213–2225. doi: 10.1101/gad.285726.116

Figure 5.

Figure 5.

Sequential regulation of ced-3 mRNA translation by PUF-8, GLD-1, CGH-1, and MEX-3. Model of sequential translation inhibition of ced-3 in the C. elegans germline and embryos. GLD-1 regulates apoptosis in two points of the apoptotic pathway: upstream at the level of p53 tumor suppressor cep-1 and at the point of no return, where it coregulates ced-3 together with PUF-8, CGH-1, and MEX-3. At the right is an image of the adult C. elegans gonad, adding spatial context to the ced-3 regulation by RBPs: PUF-8 inhibits ced-3 in the mitotic and early meiotic zones, GLD-1 inhibits ced-3 throughout the early and late meiotic zones, CGH-1 inhibits ced-3 in the late meiotic zone and oocytes, and MEX-3 inhibits ced-3 in the embryos. Whether MEX-3, PUF-8, and CGH-1 regulate ced-3 directly or indirectly via other factors remains to be determined.