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. Author manuscript; available in PMC: 2017 Mar 9.
Published in final edited form as: Cell Host Microbe. 2016 Feb 25;19(3):361–374. doi: 10.1016/j.chom.2016.02.001

Fig. 7. Comparison of B. dermatitidis and human DppIV.

Fig. 7

(A) Primary amino acid sequence alignment of the catalytic region of B. dermatitidis DppIVA (Gene ID: BDFG_07406, Uniprot ID: T5BJB9) and human DppIV (Uniprot ID: P27487), which are 44% identical and 59% similar as determined by NCBI blastp (protein-protein BLAST). Identical amino acids are bolded and boxed in gray. (B) (Top Left) 3D Model of the previously crystalized human DppIV protein with the catalytic triad (aspartic acid, histidine, serine) boxed. (Top Center) Predicted 3D structure of B. dermatitidis DppIVA generated in I-TASSER with the catalytic triad (aspartic acid, histidine, serine) boxed. (Top Right) Overlay of 3D structures of human and B. dermatitidis DppIV. (Bottom Left) Zoom-in of the human DppIV catalytic triad (Bottom Right) and B. dermatitidis DppIV catalytic triad. All 3D models were made using PyMOL (The PyMOL Molecular Graphics System). (See also Figure S7)