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. 2016 Oct 27;4:e2635. doi: 10.7717/peerj.2635

Figure 4. Captive bubble activity of synthetic surfactants containing glycerophospholipids plus SP-B/C peptides.

Figure 4

Dynamic surface activity of synthetic lipid/peptide lung surfactants was studied with a captive bubble surfactometer at 37°C. Synthetic surfactants studied were 5:3:2 (weight ratio) DPPC:POPC:POPG (lipids alone) combined with 1.5% S-MB DATK + 1.5% SP-Css ion-lock 1 peptides together or with 3% of either peptide alone. Each sample includes two plots, the lower plot represents minimum surface tension and the upper represents maximum surface tension. Synthetic glycerophospholipid/peptide surfactants were all highly active in reducing minimum surface tension to ≤1 mN/m on the captive bubble surfactometer throughout 10 consecutive compression-expansion cycles. See text for details. Data are Mean ± S.E.M. for N = 4–8.