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Design and construction of pRNA-3WJ nanoparticles harboring prostate-specific membrane antigen (PSMA) binding aptamer and anti-miRNA LNA. (a) The sequence and secondary structure of bacteriophage phi29 packaging RNA (pRNA). (b) 3WJ core of pRNA. (c) Design of pRNA-3WJ nanoparticles harboring PSMA binding aptamer and anti-miRNA LNA. (d) 10% native TBM PAGE of A9g-3WJ-anti-miR21 nanoparticle.
