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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Cell Rep. 2016 Oct 4;17(2):328–335. doi: 10.1016/j.celrep.2016.09.014

Figure 3. Amino-terminal domain subunits of the AMPA receptor decouple upon desensitization and are stabilized in the presence of stargazin.

Figure 3

LRET lifetimes between the proximal GluA2 subunits at site 23 (Top Panel) and at site 27 (Bottom Panel). Insets show location of sites 23 and 27 on the AMPA receptor. A) and E): Apo or resting condition. B) and F): Desensitized condition with the presence of 1 mM glutamate. C) and G): Open condition with the presence of 1 mM glutamate + 100 μM CTZ. D): GluA2 L483Y non-desensitizing mutant (open conformation) in the presence of 1 mM glutamate. See also Figure S4.