Figure 2. Research tool summary and questions to be answered.

Although recent advances provide tremendous insight into the regulatory functions of eosinophils, important questions remain. With the increasing number of tools available (upper panel), progress in the listed areas (lower panel, outside blue boxes), in the light of key eosinophil regulation elements (inside ovals) will be interesting and crucial to understanding the still enigmatic function of eosinophils. EOS, eosinophils; EPO-DT, EPO-driven diphtheria toxin expression mice; EMT, epithelial-mesenchymal transition; DAMP, damage-associated molecular pattern; PAMP, pathogen-associated molecular pattern; miR, microRNA; GOI, gene of interest; Tg, transgenic; (D)KO, (double)knockout.