Table 4.
Adjusted* Odds Ratios† (95% confidence intervals) for prevalent baseline Elevated Hs-cTnT and Adjusted* Hazard Ratios‡ for Events, according to categories of diastolic BP after stratification by baseline systolic BP (mmHg) (N=11,565)
| Cross-Sectional Analysis for Elevated Hs-cTNT (≥14 ng/L) |
Prospective Proportional Hazards Analysis for Incident Outcomes |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Visit 2 Diastolic BP |
Visit 2 Systolic BP |
n/N | Odds Ratio (95% CI) |
p- value |
n/N | CHD HR (95% CI) |
p- value |
n/N | Mortality HR (95% CI) |
p- value |
| <60 mm Hg |
<120 mm Hg |
26/ 957 |
1.16 (0.47–2.86) |
0.74 | 130/ 957 |
1.05 (0.71–1.54) |
0.81 | 281/ 957 |
1.23 (0.89–1.70) |
0.22 |
| 60–79 mm Hg | 109/ 4891 |
0.86 (0.40–1.88) |
0.71 | 637/ 4891 |
0.97 (0.69–1.36) |
0.85 | 1061/ 4891 |
1.07 (0.79–1.45) |
0.66 | |
| 80–89 mm Hg | 9/227 | 1 (reference) |
. | 37/ 227 |
1 (reference) |
. | 45/ 227 |
1 (reference) |
. | |
| ≥90 mm Hg | 0/7 | --- | --- | 0/7 | --- | --- | 1/7 | 0.91 (0.12–6.60) |
0.94 | |
| <60 mm Hg |
120–139 mm Hg |
9/101 |
2.49 (1.06–5.84) |
0.03 | 26/ 101 |
1.71 (1.11–2.63) |
0.01 | 49/ 101 |
1.25 (0.91–1.71) |
0.17 |
| 60–79 mm Hg | 98/ 2507 |
0.90 (0.59–1.36) |
0.61 | 497/ 2505 |
1.17 (0.97–1.40) |
0.09 | 800/ 2505 |
0.99 (0.85–1.14) |
0.85 | |
| 80–89 mm Hg | 41/ 1033 |
1 (reference) |
. | 176/ 1033 |
1 (reference) |
. | 275/ 1033 |
1 (reference) |
. | |
| ≥90 mm Hg | 7/144 | 1.15 (0.50–2.64) |
0.75 | 31/ 144 |
1.19 (0.81–1.75) |
0.36 | 37/ 144 |
1.00 (0.71–1.41) |
0.99 | |
| <60 mm Hg |
≥ 140 mm Hg |
4/29 | 1.45 (0.38–5.53) |
0.59 | 9/29 | 1.46 (0.73–2.92) |
0.29 | 15/29 | 0.97 (0.57–1.65) |
0.90 |
| 60–79 mm Hg | 57/ 579 |
0.94 (0.60–1.46) |
0.77 | 165/ 579 |
1.31 (1.03–1.66) |
0.03 | 298/ 579 |
1.02 (0.86–1.21) |
0.78 | |
| 80–89 mm Hg | 52/ 642 |
1 (reference) |
. | 137/ 642 |
1 (reference) |
. | 277/ 642 |
1 (reference) |
. | |
| ≥90 mm Hg | 43/ 448 |
0.87 (0.54–1.41) |
0.58 | 98/ 448 |
1.02 (0.78–1.33) |
0.89 | 200/ 448 |
1.02 (0.85–1.24) |
0.81 | |
Adjusted for: age (years), race-center, gender, body mass index in kg/m2, smoking (current; former; never), alcohol intake (current; former; never), hypertension medication use (yes, no), diagnosed diabetes (yes, no), LDL-cholesterol (mg/dL), HDL-cholesterol (mg/dL), triglycerides (mg/dL), current use of cholesterol-lowering medication (yes or no), and estimated glomerular filtration rate in mL/min/1.73m2.
Logistic model for cross-sectional association between diastolic BP and baseline elevated hs-cTnT
Cox model for prospective association between diastolic BP and incident events
Significant values in bold.
CHD=coronary heart disease, Hs-cTnT= high-sensitivity Troponin T, other abbreviations as per Table 1.