Table 1. Molecular descriptors of the lead compounds.

HBA – Hydrogen bond acceptor, HBD – Hydrogen bond donor, HY – Hydrophobic, RA – Ring aromatic, MR – Molar refractivity, NROTB – No. of rotatable bonds, cLog P – log octanol/water partition coefficient, PSA – Polar surface area, NSC – No. of stereo centers.

S.No	Mwt	cLog P	HBA	HBD	HY	RA	MR	NROTB	PSA(A 2)	NSC
1	324	2.8	8	0	2	4	83.82	3	74.98	0
2	281	2.46	5	2	2	4	76.92	1	74.70	0
3	359	4.22	7	0	3	6	78.47	4	73.84	1
4	358	3.86	6	1	3	6	100.70	1	77.36	1
5	311	3.15	9	0	2	4	78.65	2	94.50	0