Skip to main content
. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Depress Anxiety. 2016 Oct;33(10):907–916. doi: 10.1002/da.22497

Figure 1.

Figure 1

BDNF isoforms and their receptors. BDNF is initially synthesized as the precursor protein proBDNF, which is cleaved to release the prodomain and mature BDNF. All three BDNF isoforms display biological functions. In BDNF isoforms containing the Val66Met SNP, the prodomain binds to SorCS2, which in turn interacts with the p75NTR to induce growth cone pruning. proBDNF binds specifically to p75NTR, which leads to apoptosis and pruning of dendritic spines through interaction with sortilin and SorCS2, respectively. Mature BDNF binds preferentially to TrkB receptors, activating downstream signaling cascades resulting in neuronal survival, differentiation, and synaptic plasticity.