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Adolescent mice homozygous for the BDNF Val66Met polymorphism exhibit reduced extinction learning, which persists into adulthood. Average freezing behavior during early (extinction day 1) and late (extinction day 4) extinction trials of BDNF WT (Val/Val) and knock-in (Met/Met) mice during (A) early development, (B) adolescence, and (C) adulthood. All results are presented as means ± SEM obtained from 3–10 mice per group. *P < .001. P, postnatal day.
