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pH gating of full-length and truncated Cx46 channels. Effect of 100% CO2 on the Gj in cell pairs expressing full-length Cx46 (A) or Cx46_D251tr (B) subunits. Channels of Cx46_D251tr rapidly closed during cytoplasmic acidification with similar-onset kinetics as full-length Cx46, indicating that C-terminal truncation did not eliminate pH gating. Junctional conductance recovered to control values on washout of CO2. Similar results were obtained in four to five other cell pairs.
