Table 1.
Summary of Experimental Design and Results Contained in 38 Articles that Matched Study Criteria for Regenerative Effects of Adipose Tissue on Peripheral Nerve Injuries
| 1st Author, YearCitation |
Fat processing method (animal) |
Nerve (animal) |
Nerve gap + repair method |
Control group repair method |
Time | Functional outcomes | MW | H/I | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WTM | NCS | EF | SF | ||||||||
| Papalia, 201343 | Whole fat graft (rat) | Median (rat) | 10-mm + conduit | Muscle-vein graft | 6 months | † | † | ||||
| Kilic, 201344 | Whole fat graft (rat) | Sciatic (rat) | Crush + none | None | 4 weeks | * | NS | * | |||
| Suganuma, 201345 | uuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 2 weeks | * | |||||
| Mohammadi, 201442 | uuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 12 weeks | * | * | * | * | ||
| Song, 201446 | uuASC (mouse) | cavernous (mouse) | Crush + none | PBS | 2 weeks | * | * | ||||
| Ghoreishian, 201347 | cuASC (dog) | Facial (dog) | 7-mm + conduit | Empty conduit | 12 weeks | * | NS | ||||
| Luo, 201248 | cuASC (dog) | Sciatic (dog) | 50-mm + conduit | Empty conduit | 24 weeks | * | |||||
| Jeong, 201349 | cuASC (human) | Cavernous (rat) | Crush + none | None | 4 weeks | * | * | ||||
| Piao, 201238 | cuASC (human) | Cavernous (rat) | Crush + none | None | 4 weeks | * | * | ||||
| You, 201350 | cuASC (human) | Cavernous (rat) | Dissection + none | PBS | 4 weeks | * | NS | ||||
| Marconi, 201232 | cuASC (human) | Sciatic (mouse) | Crush + none | PBS | 3 weeks | * | * | ||||
| Santiago, 200951 | cuASC (human) | Sciatic (rat) | 6-mm + conduit | Empty conduit | 12 weeks | NS | NS | * | |||
| Masgutov, 201552 | cuASC (human) | Sciatic (rat) | 10-mm + autograft | Autograft + NaCl | 65 days | * | |||||
| Fandel, 201253 | cuASC (rat) | Cavernous (rat) | Crush + none | PBS | 4 weeks | * | * | ||||
| Qiu, 201254 | cuASC (rat) | Cavernous (rat) | Crush + none | Saline | 12 weeks | * | * | ||||
| Ying, 201355 | cuASC (rat) | Cavernous (rat) | Crush + none | PBS | 3 months | * | * | ||||
| Liu, 201156 | cuASC (rat) | Sciatic (rat) | 15-mm + end-to-end | Empty allograft | 12 weeks | * | * | * | |||
| Dai, 201357 | cuASC (rat) | Sciatic (rat) | 15-mm + conduit | Empty conduit | 8 weeks | NS | NS | * | |||
| Erba, 201058 | cuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 2 weeks | * | |||||
| Carriel, 201311 | cuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 12 weeks | * | * | * | * | ||
| Mohammadi, 201359 | cuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 12 weeks | * | * | * | |||
| Shen, 201260 | cuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 8 weeks | * | * | * | |||
| Wei, 201161 | cuASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 24 weeks | * | * | * | |||
| Sun, 2011(A)62 | cuASC (rat) | Facial (Rat) | 8-mm + conduit | Empty conduit | 8 weeks | * | * | ||||
| Kim, 201463 | cuASC/cdASC (human) | Sciatic (rat) | 15-MM + CONDUIT | Empty conduit | 6 weeks | */* | */* | ||||
| Sun, 2011(B)64 | cuASC/cdASC (rat) | Facial (rat) | 8-mm + conduit | Empty conduit | 8 weeks | NS/* | */* | NS/* | |||
| Schaakxs, 201365 | cuASC/cdASC (rat) | Sciatic (rat) | Bisect + end-to-end | Growth medium | 1 month | NS/* | NS/* | NS/* | |||
| Orbay, 201266 | cuASCs/cdASCs (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 6 months | */* | */* | ||||
| Lopatina, 201131 | cdASC (human) | Peroneal (mouse) | Crush + none | Growth medium | 11 days | * | |||||
| Hsueh, 201467 | cdASC (human) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 6 weeks | NS | * | * | |||
| Li, 201368 | cdASC (mouse) | Sciatic (mouse) | 10-mm + conduit | Empty conduit | 4 weeks | * | |||||
| Zhao, 201069 | cdASC (mouse) | Sciatic (mouse) | 14-mm + conduit | Empty conduit | 12 weeks | * | NS | * | |||
| Tomita, 201270 | cdASC (rat) | Peroneal (rat) | 3-mm + conduit | Empty conduit | 10 weeks | * | * | * | * | ||
| di Summa, 201026 | cdASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 2 weeks | * | |||||
| di Summa, 201171 | cdASC (rat) | Sciatic (rat) | 10-mm + conduit | Empty conduit | 15 weeks | * | * | * | |||
| Schaakxs, 201572 | cdASC (rat) | Sciatic (rat) | 10-mm + fibrin strips | Fibrin strips | 12 weeks | * | NS | * | * | ||
| Wang, 201273 | cdASC (rat) | Sciatic (rat) | 15-mm + conduit | Empty conduit | 12 weeks | * | * | * | * | ||
| Matsumine, 201440 | DFAT (rat) | Facial (rat) | 7-mm + conduit | Empty conduit | 13 weeks | * | * | ||||
Abbreviations: MW, Muscle Weight; H/I, Histology/Imaging; WTM, Walking Track and Motor Analysis; NCS, Nerve Conduction Studies; EF, Erectile Function; SF, Sensory Function; uuASCs, uncultured undifferentiated adipose-derived stem cells; cuASCs, cultured undifferentiated adipose-derived stem cells; cdASCs, cultured differentiated adipose-derived stem cells; DFAT, dedifferentiated mature adipocytes; PBS, Phosphate buffered saline; NaCl, Sodium chloride. Decellularized nerve grafts and vein grafts were labeled as nerve conduits. “Empty” refers to no adipose cells added.
Control groups all had the same nerve injuries as the listed experimental groups.
Significance was determined by referring to the corresponding control group in each major category tested: *P < 0.05 (statistically significant improvement),
P < 0.05 (statistically significant decline),
NS (not significant, P > 0.05).