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. 2016 Nov 1;11(11):e0165916. doi: 10.1371/journal.pone.0165916

Fig 2. Representative photograph showing clinical signs of inflammation in rats’ joints examined on day 22 after CFA injection.

Fig 2

(a, b), normal control rats, (c-f) untreated arthritic rats showing severe swelling and redness in both hind paws involving the metatarsal joints and extending to the ankle joint in (c) and (d). Note the severe erosion and amputated toes in (e), while less severe swelling was observed in the forepaws in (f). Rats from the ASMA (g) and ATSA (h)-treated arthritis groups showing less intense inflammatory signs in the right hind paw and almost ameliorated inflammation in the other paws. CFA, complete Freund’s adjuvant; ASMA, autoclaved Schistosoma mansoni antigen and ATSA, autoclaved Trichinella spiralis antigen.