Table 2.
Patient group/placebo (n = 11) | Patient group/blue‐blocking (n = 12) | Healthy controls (n = 45) | |
---|---|---|---|
Current episode | |||
YMRS score at start of intervention, mean (SD) | 27.0 (7.1) | 23.4 (8.0) | |
Psychotic symptoms | 9/11 | 8/12 | |
Hospitalized against own will | 8/11 | 6/12 | |
Demographic variables | |||
Age, years, mean (SD) | 49.8 (13.8) | 43.0 (11.0) | 42.3 (10.8) |
Sex, male | 9/11 | 7/12 | 22/45 |
Highest level of education completed | |||
High school | 4/11 | 4/12 | 6/45 |
High school/vocational studies | 3/11 | 6/12 | 7/45 |
University/higher education | 4/11 | 2/12 | 32/45 |
Employment status | |||
Unemployed | 2/11 | 1/12 | 0/45 |
Student | 1/11 | 0/12 | 1/45 |
Employed | 3/11 | 6/12 | 42/45 |
Retired | 1/11 | 1/12 | 2/45 |
Disability benefit | 4/11 | 4/12 | 0/45 |
Marital status | |||
Single | 3/11 | 4/12 | |
Cohabiting | 1/11 | 2/12 | |
Married | 2/11 | 3/12 | |
Divorced | 5/11 | 3/12 | |
Clinical characteristics from medical history | |||
Family historya | 6/10 | 4/12 | |
Self‐reported age at first affective episode, years, mean (SD) | 24.7 (12.1) | 23.0 (10.9) | |
Age at first psychiatric hospital stay, years, mean (SD) | 32.9 (4.0) | 31.7 (3.5) | |
Duration of illness, years, mean (SD) | 22.8 (3.8) | 18.0 (3.1) | |
Psychotic mania in medical history | 10/11 | 10/12 | |
Self‐reported no. of depressive episodes, mean (SD) | 7.2 (2.8)b | 12.0 (8.0)b | |
No. of previous psychiatric hospital stays, mean (SD) | 7.2 (2.2) | 4.6 (1.2) | |
No. of psychiatric hospital stays for mania, mean (SD) | 7.0 (2.2) | 2.9 (0.8) | |
No. of psychiatric hospital stays for depression, mean (SD) | 0.7 (0.3) | 1.0 (0.5) | |
Previous suicide attempts | 2/11 | 3/12 | |
Lifetime medication use | |||
Antidepressants | 2/11 | 7/12 | |
Antipsychotics | 9/11 | 10/12 | |
Anticonvulsants | 8/11 | 9/12 | |
Lithium | 7/11 | 6/12 | |
Hypnotics/sedatives | 8/11 | 7/12 | |
Anxiolytics | 4/11 | 6/12 |
SD = standard deviation; YMRS = Young Mania Rating Scale.
Relatives with bipolar disorder, affective/anxiety disorders, psychotic disorders or psychiatric hospital stays.
Data missing for one subject.