Table 5.
TK1 and Neoplasia Index interval likelihood ratios based upon number of dogs within each group
| Interval TK1 (U/L) | Car | Hist | HSA | LSA | Mast | Mel | Ost | Othr | Sar | Ctrl | Total Cancer | Likelihood Ratio | Sens. | Spec. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0–1.9 | 1 | 0 | 0 | 1 | 2 | 1 | 3 | 3 | 3 | 87 | 14 | 0.10 | 1.00 | 0.00 |
| 2.0–5.9 | 20 | 4 | 3 | 11 | 11 | 5 | 8 | 4 | 19 | 56 | 85 | 0.94 | 0.95 | 0.56 |
| 6.0–9.0 | 14 | 2 | 0 | 10 | 6 | 0 | 5 | 2 | 5 | 5 | 44 | 5.43 | 0.61 | 0.92 |
| 9.1–19.9 | 12 | 1 | 1 | 18 | 8 | 2 | 0 | 3 | 6 | 4 | 51 | 7.86 | 0.44 | 0.95 |
| ≥20 | 6 | 2 | 3 | 43 | 1 | 0 | 0 | 1 | 3 | 4 | 59 | 9.10 | 0.27 | 0.98 |
| Total | 53 | 9 | 7 | 83 | 28 | 8 | 16 | 13 | 36 | 156 | 253 | |||
| ROC AUC | 0.866 | 0.887 | 0.891 | 0.948 | 0.837 | 0.813 | 0.783 | 0.775 | 0.841 | 0.876 | ||||
| Neoplasia index | ||||||||||||||
| 0–1.7 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 78 | 6 | 0.05 | 1.00 | 0.00 |
| 1.8–4.1 | 21 | 1 | 1 | 9 | 11 | 3 | 10 | 4 | 13 | 62 | 73 | 0.73 | 0.87 | 0.75 |
| 4.2–5.3 | 11 | 0 | 1 | 7 | 7 | 2 | 0 | 2 | 6 | 8 | 36 | 2.78 | 0.69 | 0.90 |
| 5.4–7.5 | 4 | 2 | 0 | 4 | 3 | 2 | 3 | 0 | 4 | 7 | 22 | 1.94 | 0.56 | 0.95 |
| 7.6–10 | 17 | 6 | 5 | 62 | 5 | 1 | 3 | 5 | 12 | 1 | 116 | 71.53 | 0.46 | 0.99 |
| Total | 53 | 9 | 7 | 83 | 28 | 8 | 16 | 13 | 36 | 156 | 253 | |||
| ROC AUC | 0.886 | 0.980 | 0.935 | 0.954 | 0.805 | 0.895 | 0.862 | 0.789 | 0.873 | 0.896 | ||||
Car, carcinoma; Hist, histiocytic sarcoma; HSA, hemangiosarcoma; LSA, lymphoma; Mast, mast cell; Mel, melanoma; Ost, osteosarcoma; Othr, other; Sar, sarcoma. Likelihood ratios based on total cancer group. Numbers in boxes represent number of dogs in each stratum (except for ROC, Ratio, Sensitivity, and Specificity).