Table 4.

Multivariate regression models of EORTC QLQ‐C30 global health status scores by disease stage

Variable	Level	New disease (n = 731)		Early disease (n = 1409)		Late disease (n = 180)
		Parameter estimate	P‐value	Parameter estimate	P‐value	Parameter estimate	P‐value
Intercept		37·66		35·70		37·59
Geographical location	North America	10·73	<0·0001	‐2·23	<0·0001
	Latin America	5·59		‐4·48
	Europe	‐5·32		‐9·96
	Asia	‐0·18		8·47
	Other	Reference		Reference
Albumin	<35 g/l	‐3·57	0·01
Creatinine clearance rate	<1·0 ml/s	‐4·33	<0·01
Bone lesions						6·44	0·04
ISS disease stage	I			6·65	<0·0001
	II			0·79
	III			Reference
Performance status (ECOG)	0	37·00	<0·0001	37·57	<0·0001	31·98	<0·0001
	1	25·39		26·22		21·48
	2	12·96		11·90		Reference
	≥3	Reference		Reference
Strong opioid		‐12·11	<0·0001	‐8·87	<0·0001
Weak opioid				‐5·07	<0·01
Non‐opioid analgesics						‐15·63	<0·001
R 2		0·29		0·23		0·22

ECOG, Eastern Cooperative Oncology Group; ISS, International Staging System. P‐values of <0.05 are shown in bold text.