Table 4.
Main toxicities (N:45)
| Toxicity | Grade 1 (%) | Grade 2 (%) | Grade 3 (%) | Grade 4 (%) |
|---|---|---|---|---|
| Hematologic | ||||
| Leukopenia | 6.7 | 24.4 | 46.7 | 11.1 |
| Neutropenia a | 4.4 | 8.9 | 11.1 | 66.7 |
| Thrombocytopenia | 8.9 | 2.2 | — | — |
| Anemia | 24.4 | 24.4 | 2.2 | — |
| Nonhemathologic | ||||
| Arthralgia | 8.9 | 8.9 | — | — |
| Nausea/vomiting | 8.9 | 35.6 | 6.7 | 2.2 |
| Mucositis | 11.1 | 15.6 | 8.9 | — |
| Diarrhea | 11.1 | 6.7 | — | — |
| Myalgia | 4.4 | 6.7 | 2.2 | — |
| Neurotoxicity | 6.7 | 4.4 | 2.2 | — |
| Hypertransaminases | 11.1 | 4.4 | 2.2 | — |
| Hypersensivity | 6.7 | — | — | — |
| Skin toxicity | 4.4 | 4.4 | — | — |
The DECT Trial.
a
Febrile neutropenia in nine patients (20%).