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. 2016 May 23;138(1):139–149. doi: 10.1111/jnc.13382

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© 2015 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Anti‐apoptotic effect of simvastatin in the primary spinal cord neurons was reduced following the suppression of the Wnt/β‐catenin signaling pathway. (a) The expression levels of Bcl‐2, Bax, active caspase‐9, and caspase‐3 in primary spinal cord neurons were detected using western blot analysis. (b–e) Simv observably restrained the apoptosis of spinal cord neurons after lipopolysaccharide (LPS) treatment, whereas the beneficial anti‐apoptotic effect of Simv on spinal cord neurons was destroyed after the inhibition of the Wnt/β‐catenin signaling pathway by the Wnt antagonist XAV939. NeuN was used as the loading control. Simv, simvastatin; *p < 0.05, **p < 0.01, ***p < 0.001, compared with LPS alone and XAV939‐treated groups. n = 4 per group.