Table 1.

Inhibitory Effect on Human Recombinant COX‐1 or COX‐2 Activity

Drug	COX‐1 IC50 (nmol/L) [95% CI]	COX‐2 IC50 (nmol/L) [95% CI]
S(+)‐flurbiprofen	8.97 [3.82–21.1]*	2.94 [1.41–6.12]*
Flurbiprofen	17.5 [7.37–41.4]	4.59 [2.68–7.85]
Ketoprofen	38.2 [6.87–213]*	26.1 [14.0–48.7]*
Loxoprofen‐SRS	1470 [1030–2100]*	25.9 [15.6–43.0]*
Diclofenac Na	13.0 [4.80–34.0]	4.0 [2.40–6.60]
Felbinac	14,000 [3,000–68,000]	12,000 [6,200–21,000]
Indomethacin	33.4 [9.24–121]	48.9 [41.4–57.9]

Data are expressed as the mean (95% confidence interval) obtained from four individual determinations or three individual determinations for diclofenac sodium salt (Na) and felbinac. IC₅₀ values were estimated by non‐linear least‐squares method.

*Sugimoto et al. (2016).