Skip to main content
. 2016 Jun 6;55(29):8353–8357. doi: 10.1002/anie.201602908

Figure 3.

Figure 3

IC50 values for H4(KAc)4‐mimicking peptides bearing isoxazole‐containing amino acids (substitution position indicated numerically), obtained using an AlphaScreen assay inhibiting the interaction of BRD4(1) with biotinylated H4(KAc)4. The guideline shows the IC50 value of control H4(KAc)4 peptide for comparison. IC50 values (in μm above bars) are geometric means, from 4‐parameter fittings40 to data obtained in triplicate. Error bars represent the error of the fit.