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. 2016 Jun 6;55(29):8353–8357. doi: 10.1002/anie.201602908

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© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A) A cartoon representing H4(KAc)₃K12C alkylation. B) Regions of MALDI‐TOF‐MS spectra of samples taken at the time indicated during the alkylation of H4(KAc)₃K12C under optimized conditions: 1 mm H4(KAc)₃K12C, 4 m guanidine hydrochloride, 10 mm methionine, 5 mm TCEP, 1 m CHES (pH 9), 5 mm Cl‐DMI, showing conversion from starting peptide (observed m/z 2255.09; expected m/z 2255.21) to alkylated H4(KAc)₃K12C(DMI) peptide (observed m/z 2350.07; expected m/z 2350.24).