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. 2016 Jun 6;55(29):8353–8357. doi: 10.1002/anie.201602908

Figure 5.

Figure 5

IC50 values for H4(KAc)4 analogue peptides bearing isoxazole‐containing amino‐acid substitutions at K12 (identity of substitution is shown below bars). Data were obtained from serial dilutions in an AlphaScreen assay inhibiting the interaction of BRD4(1) with biotinylated H4(KAc)4. Guideline shows IC50 value of the control H4(KAc)4 peptide for comparison. IC50 values (in μm above bars) are geometric means, from 4‐parameter fittings40 to data obtained in triplicate. Error bars represent the error of the fit. See Figure S11.