Table 3.
Inclusion of relevant experimental data on asthmatic subjects by REACH registrants and by 10 other groups of risk assessment experts
| Substance | Number of experimental studies on asthmatics | |||||
|---|---|---|---|---|---|---|
| Found in the literature | Cited in risk assessment documents from 10 sets of acute or short‐term valuesa | Used as key studies in risk assessment documents from 10 sets of acute or short‐term valuesa | Cited by registrant at the ECHA website | Used as key study by registrant | Reliability of study according to registrantb | |
| Acetaldehyde | 11 | 9 (AEGL, ERPG, REL) | 1 (REL) | – | – | – |
| Ammonia | 2 | 2 (AEGL, REL, SE‐OEL) | 1 (AEGL) | – | – | – |
| Ammonium sulphate | 7 | No document | No document | 2 | 2 | 2, 2 |
| Chlorine | 1 | 1 (AEGL, ERPG, MRL, REL, SCOEL) | 1 (AEGL, ERPG, MRL, REL, SCOEL) | – | – | – |
| Bromine (structure analogy: chlorine) | 1 | 1 (AEGL) | 1 (AEGL) | – | – | – |
| Diiron tris(sulphate) | 1 | 1 (DECOS) | 1 (DECOS) | 1 | – | 2 |
| Formaldehyde | 12 | 11 (AEGL, ERPG, MRL, REL, VSTAF, DECOS, MAK, SE‐OEL, TLV) | 4 (AEGL) | 6 | – | 2, 2, 2, 2, 2, 2 |
| Hydrogen chloride | 1 | 2 (AEGL, ERPG, REL, VSTAF, SE‐OEL, TLV) | 1 (AEGL, ERPG, REL, TLV) | – | – | – |
| Hydrogen bromide (structure analogy: hydrogen chloride) | 1 | 1 (AEGL) | – | – | – | – |
| Octyl trichlorosilane (forms hydrogen chloride upon hydrolysis) | 1 | 1 (AEGL) | 1 (AEGL) | – | – | – |
| Silicon tetrachloride (forms hydrogen chloride upon hydrolysis) | 1 | 1 (AEGL) | 1 (AEGL) | – | – | – |
| Trichlorosilane (forms hydrogen chloride upon hydrolysis) | 1 | 1 (AEGL) | 1 (AEGL) | – | – | – |
| Hydrogen sulphide | 1 | 1 (AEGL, MRL, REL, VSTAF, DECOS, SCOEL) | 1 (AEGL, MRL) | 1 | – | 4 |
| Nitric acid | 4 | 5 (AEGL, ERPG, REL, VSTAF, SE‐OEL) | 2 (ERPG, REL) | 1 | – | 4 |
| Dinitrogen tetroxide (vaporizes and dissociates into nitrogen dioxide in air) | 44 | 1 (AEGL) | 1 (AEGL) | – | – | – |
| Sodium hydrogen sulphate | 3 | No document | No document | – | – | – |
| Sodium nitrate | 3 | No document | No document | – | – | – |
| Sulphur dioxide | 66 | 48 (AEGL, ERPG, MRL, REL, VSTAF, DECOS, SCOEL, SE‐OEL) | 10 (AEGL, ERPG, MRL, REL, DECOS, SCOEL) | 46 | 11 | 1 (35), 2 (11) |
| Thionyl chloride (structure analogy: sulphur dioxide) | 66 | 2 (AEGL) | – | 2 | 2 | Not stated |
| Sulphuric acid | 38 | 38 (AEGL, ERPG, REL, VSTAF, MAK, SCOEL, SE‐OEL, TLV) | 7 (AEGL, ERPG, REL, TLV) | 2 | – | 2, 2 |
| Sulphur trioxide (forms sulphuric acid upon hydrolysis) | 38 | 28 (AEGL) | 2 (AEGL) | 2 | 2 | 2, 2 |
| Chlorosulphonic acid (structure analogy: sulphuric acid) | 38 | 28 (AEGL) | 2 (AEGL) | – | – | – |
| 4‐methyl‐m‐phenylene diisocyanate | 2 | 2 (AEGL, ERPG, MAK, SE‐OEL) | 1 (AEGL, ERPG) | – | – | – |
–, not cited; AEGL, acute exposure guideline levels; DECOS, limits recommended by the Dutch Expert Committee on Occupational Standards; ERPG, emergency response planning guidelines; MAK, maximum concentration at the workplace; MRL, minimal risk levels; REL, reference exposure levels; SCOEL, limits recommended by the Scientific Committee on Occupational Exposure Limits; SE‐OEL, Swedish occupational exposure limits; TLV, threshold limit values; VSTAF, French acute toxicity threshold values.
As reported in Johansson et al. (2012).
Given as Klimisch codes: 1 = reliable without restrictions; 2 = reliable with restrictions; 3 = not reliable; 4 = not assignable (Klimisch et al. 1997).