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. Author manuscript; available in PMC: 2017 Nov 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2016 Sep 23;311:74–87. doi: 10.1016/j.taap.2016.09.022

Figure 2. Phylogenetic analysis of heme oxygenase proteins.

Figure 2

Protein alignments and tree construction were performed in MEGA6. Evolutionary history was inferred by using the Maximum Likelihood method. The Bootstrap method was used (1000 replicates) for the Test of Phylogeny. D. melanogaster) HMOX (NP_524321.1) was used as an out-group. HMOX1 proteins: D. rerio Hmox1a: NP_001120988.1; D. rerio Hmox1b: KX664458; T. ruprides Hmox1: UniProtKB - O73688; T. nigroviridis Hmox1: GenBank: CAF95107.1; H. sapiens HMOX1: NP_002124.1; R. norvegicus HMOX1: NP_036712.1; G. gallus HMOX1:NP_990675.1. Hmox2 proteins: D. rerio Hmox2a: NP_001096609.1; D. rerio Hmox2b: XP_002661145.1; T. nigroviridis Hmox2: GenBank: CAG00172.1; T. ruprides Hmox2: Ensemble: ENSTNIP00000012632.1m; H. sapiens HMOX2: NP_002125; R. norvegicus HMOX2: NP_077363.1; G. gallus HMOX2: XP_414960.1.