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. 2016 Nov 1;11(11):e0165879. doi: 10.1371/journal.pone.0165879

Table 4. Cost estimates and disability weights used in the model.

Parameter Baseline Range Sources
Program costs (USD)
Vaccines per dose
HepB birth 0.16 0.14–0.186 [34][35]
HBIG 23 14.5–31.25 [36][37]
HBsAg rapid test kit 0.63 0.5–0.8 [22]
Injection supplies per dose (USD)
AD syringes 0.053 - [20]
Safety boxes 0.0064 - [20]
Wastage rates (%)
Vaccines
HepB birth 25 10–50 [20]
HBIG 25 10–50 Assumed
HBsAg rapid test kit 10 0–20 Assumed
AD syringes 10 0–20 [20]
Safety boxes 10 0–10 [20]
Average treatment cost (USD)
Costs per morbid episode per year 38.08 11.14–94.35 [13]
Travel and time costs
Average transportation per travel (USD) 0.31 0.2–0.5 [11]
Average time for travel/waiting/treatment at public 2.3 0.96–2.76 [11]
health facilities (hours)
Average number of outpatient visit 1 0.5–2 [11]
Average hourly wagea (USD) 1.23 1.1–1.4 [40]
Costs for health system strengthening (USD, million)
Selective vaccination - 0.06–6 [47]
Universal vaccination - 0.06–6 [47]
Disability weights for
Chronic hepatitis 0.36 0.32–0.4 [42]
Compensated cirrhosis 0.31 0.28–0.495 [42][43]
Decompensated cirrhosis 0.52 0.12–0.92 [42][44]
HCC 0.73 0.59–0.93 [42][43]
Discount rate (%) 3 1.5–5 [46]

HepB, Hepatitis B; HBIG, Hepatitis B Immune Globulin; HBsAg, Hepatitis B surface Antigen; AD, Auto-Disable; HCC, Hepatocellular carcinoma

a. The opportunity cost of productivity loss occurs during ages from 20 years to 60 years.

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