Table 2. Incidence and adjusted hazard ratio of inflammatory bowel disease stratified by sex, age and comorbidity (yes/no) between alcohol intoxication and non-alcohol intoxication cohorts.
| Alcohol intoxication | Compared to non-alcohol intoxication cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| No | Yes | |||||||
| Variables | Event | PY* | Rate# | Event | PY* | Rate# | IRR‡(95% CI) | Adjusted HR†(95% CI) |
| Overall | 86 | 1756493 | 0.49 | 94 | 350055 | 2.69 | 5.48(5.33–5.65)*** | 3.17(2.19–4.58)*** |
| Crohn disease (CD; ICD-9-CM: 555) | 34 | 1756493 | 0.19 | 49 | 350055 | 1.40 | 7.23(7.01–7.46)*** | 4.40(2.58–7.51)*** |
| Ulcerative colitis (UC; ICD-9-CM: 556) | 52 | 1756493 | 0.3 | 45 | 350055 | 1.29 | 4.34(4.21–4.48)*** | 2.33(1.39–3.90)*** |
| Sex | ||||||||
| Women | 5 | 171353 | 0.29 | 9 | 37358 | 2.41 | 8.26(7.50–9.09)*** | 6.75(1.82–25.0)** |
| Men | 81 | 1585140 | 0.51 | 85 | 312697 | 2.72 | 5.32(5.16–5.49)*** | 2.90(1.97–4.27)*** |
| Age, year | ||||||||
| <45 | 34 | 1016697 | 0.33 | 62 | 210968 | 2.94 | 8.79(8.44–9.15)*** | 5.08(3.02–8.55)*** |
| ≥45 | 52 | 739796 | 0.70 | 32 | 139087 | 2.30 | 3.27(3.13–3.43)*** | 1.98(1.15–3.42)** |
| Comorbidity | ||||||||
| No | 73 | 1603327 | 0.46 | 21 | 135556 | 1.55 | 3.40(3.27–3.54)*** | 3.17(1.95–5.16)*** |
| Yes | 13 | 153166 | 0.85 | 73 | 214500 | 3.40 | 4.01(3.67–4.38)*** | 3.89(2.13–7.10)*** |
PY*, person-year
Rate#, incidence rate (per 10 000 person-years)
IRR‡, incidence rate ratio
Adjusted HR†: multivariate analysis including age, sex, and comorbidities
*P < .05
**P < .01
***P < .001