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. 2016 Nov 1;11(11):e0165411. doi: 10.1371/journal.pone.0165411

Table 3. Incidence rate and hazard ratio for inflammatory bowel disease stratified by severity of alcohol intoxication.

Severity of alcohol intoxication Event Rate Adjusted HR(95% CI)
Non-alcohol intoxication cohort 86 0.49 Ref
Alcohol intoxication cohort
    Mild (T1) 33 1.21 1.76(1.13–2.73)**
    Moderate (T2) 28 5.12 6.83(4.13–11.3)***
    Severe (T3) 33 14.14 19.9(12.1–32.8)***
p for trend# < .0001
Number of hospitalizations due to alcohol intoxication during the follow-up time
    1 58 2.34 3.15(2.16–4.59)***
    2 16 3.18 3.34(1.82–6.12)***
    ≥3 20 3.87 3.09(1.62–5.89)***
p for trend# < .0001

Rate, incidence rate, per 10 000 person-years; HR, adjusted hazard ratio; CI, confidence interval; T1, first tertile; T2, second tertile; T3, third tertile. Severity of alcoholism = (total length of hospital stay due to alcohol intoxication during the follow-up duration) ÷ (length of follow-up duration).

Adjusted for age, sex, and each comorbidities.

# The p for trend was estimated by the Cox proportional hazard regression model.

**P < .01

***P < .001