Table 2. Reported effects of pregnancy on hepatic enzyme activity.

Enzyme	Effect of Pregnancy [Reference]	Substrate Examples
CYP1A2	Decreased [18]	Paracetamol, propranolol, theophylline
CYP2B6	Increased [21]	Methadone, efavirenz, sertraline
CYP2C8	Increased [22]	Verapamil, fluvastatin
CYP2C9	Increased [23,24]	Glyburide, phenytoin
CYP2C19	Decreased [23,25]	Proguanil, indomethacin, citalopram, escitalopram
CYP2D6	Increased [17]	Alprenolol, codeine, fluoxetine
CYP2E1	Increased [26]	Disulfiram, theophylline
CYP3A4	Increased [27]	Darunavir, citalopram
Uridine 5′-diphospho-glucuronosyltransferases	Increased [28]	Lamotrigine, morphine