Table 6. Antibiotics: inconsistent studies of pregnancy-associated pharmacokinetic changes (percent calculated as pregnant/non-pregnant values).
| Drug [Reference] | Number of Studies | Total Number of Women (Nonpregnant/Pregnant) | Average Quality | Distribution Parameters | Exposure Parameters | Elimination Parameters | Potential Sources for Inconsistency | Trimester |
|---|---|---|---|---|---|---|---|---|
| Ampicillin [67,68] | 2 | 32/35 | 11.5 | V d 96% & | C trough 108% & , AUC 79% & | Cl 122% & , inconsistent data for t 1/2 # | Comparison group selection | 3rd |
Significant results are marked in bold.
&Parameter reported in one study.
#Numbers not provided.