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. 2016 Nov 1;11(11):e0165922. doi: 10.1371/journal.pone.0165922

Fig 5. Hif1α protein accumulation is suppressed by SERMs.

Fig 5

Western blot analysis of Raw264.7 cells cultured in hypoxic conditions with or without tamoxifen (TAM, 0.5μM, 0.25μM) (A), raloxifene (RAL, 1μM) (B), or bazedoxifene (BZA, 1μM) (C) or estradiol (E2, 1μM). Vinculin expression serves as an internal control. In all panels, –(minus) symbols in the hypoxia row indicate normoxic conditions. Representative data of at least three independent experiments are shown.