Table 4.
Relationship between stromal SPARC reactivity in biopsy or surgical specimens and tumor response to nab-paclitaxel in NSCLC
| Tumor response | Stromal SPARC reactivity
|
P-value | |||
|---|---|---|---|---|---|
| (−) | (+) | (++) | NE | ||
| PR (n=20) | 0 | 2 | 13 | 5 | 0.002* |
| SD (n=13) | 2 | 7 | 2 | 2 | 0.02** |
| PD (n=10) | 3 | 2 | 3 | 2 | |
Notes:
*
PR vs SD;
**
PR vs PD evaluable cases only.
Abbreviations: SPARC, secreted protein acidic and rich in cysteine; NSCLC, non-small-cell lung cancer; NE, not evaluated; PR, partial response; SD, stable disease; PD, progressive disease.