Table 1.
IPT-related parameters.
| Name | Description | Value | References |
|---|---|---|---|
| v | Risk ratio: DS reactivations allowed while on IPT | Prior: 0.28 (0.10 0.8) Posterior: 0.29 (0.1,0.8) |
[11] (TST+) |
| (not coded) | Proportion DS reinfections allowed on IPT | 0 | assumed |
| alipt | rate of INH resistance on IPT among people with latent TB (year−1) | Prior: 0.025 (0.001, 0.049) Posterior: 0.025 (0.001, 0.05) |
[14] (smaller than resistant rate on 1st line therapy) |
| a | Rate of INH resistance on IPT among people with active TB (year−1) | Same as rifampicin-resistant TB on 1st line therapy | [33] |
| γlipt | Rate of removal of latent TB strains on IPT (year−1) | Prior: 2.5 (0.125, 4.875) Posterior: 1.0 (0.03, 4.4) |
[8] |
| γipt | Cure rate of active TB on IPT (year−1) | Same as rifampicin- resistant TB on 1st line therapy | [33] |
| m_ipt_m | Susceptibility to reinfection after removal of latent TB strains 1: same as susceptible 0: same as latently infected |
Prior: 0.5 (0.025, 0.975) Posterior: 0.52 (0.02, 0.97) |
Assume no information |
| μi | mortality rate with detected HIV, on IPT (year−1) | 0.0006 + baseline mortality rate with detected HIV | [11] |
| μti | mortality rate with active TB, with detected HIV, on IPT (year−1) | Same as 1st line treatment rifampicin-resistant TB (10.6% of people die during therapy) | [34–38] |
| θl | proportion of people with latent TB who receive IPT upon HIV detection (>1 dose) | Before 2004: 0 2004–2008: 0.9 2008–2017: 0 2017 on (IPT scenarios): 0.9 |
assumed |
| θs | proportion of TB susceptibles who receive IPT upon HIV detection (>1 dose) | Same as θl | [1]; WHO recommendations don’t require TST |
| ϕ | proportion of people who start IPT after successfully finishing treatment | 0 | assumed |
| w | rate of IPT completion/dropout (year−1) | 2.147 (6 month), 0.147 (realistic continuous), or 0 (ideal continuous) | Dropout based on [13] |
| e | Rate allowed to start IPT from detected HIV compartment (year−1) | Pre-2017: 0 2017-2017.5: 2.77 Post 2017.5: 0 |
Assume 75% of detected people may start IPT |
Distributions are reported as median (2.5th percentile, 97.5th percentile). A complete list of all parameters can be found in the Appendix.