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. Author manuscript; available in PMC: 2017 Oct 20.
Published in final edited form as: Mol Cell. 2016 Oct 13;64(2):236–250. doi: 10.1016/j.molcel.2016.09.009

Figure 4. Structure-Based Mutants Disrupt Casp-8tDED Filament Formation in Vitro and in Cells.

Figure 4

(A) Gel filtration profiles of WT and mutant Casp-8tDED showing the filamentous, void fraction and the monomeric fraction from a Superdex 200 column.

(B) Morphology of transfected mCherry-fused WT and mutant Casp-8tDED visualized by fluorescence microscopy. Hoechst was used to stain nuclei.

See also Figure S4.