Table 3.
Baseline Left Ventricular Structure and Function and Coronary Anatomy by Age
| Variable | Baseline Age Quartiles | P-value for Trend | |||
|---|---|---|---|---|---|
| Q1 (Age≤54 years) (n=330) | Q2 (54<Age≤60 years) (n=295) | Q3 (60<Age≤67 years) (n=279) | Q4 (Age>67 years) (n=308) | ||
| Structure and function: | |||||
| LVEF (%) | 28(22,33) | 28(23,35) | 26(21,33) | 28(22,34) | 0.496 |
| ESVI | 81(62,103) | 81(61,98) | 77(60,105) | 77(61,98) | 0.179 |
| EDVI | 117(92,144) | 113(90,139) | 109(87,141) | 108(87,135) | 0.012 |
| E velocity (m/s) | 0.70(0.30,0.90) | 0.70(0.50,0.90) | 0.70(0.50,0.90) | 0.60(0.50,0.85) | <0.001 |
| A velocity (m/s) | 0.60(0.40,0.80) | 0.70(0.50,0.80) | 0.73(0.60,0.90) | 0.70(0.60,0.90) | <0.001 |
| E/A ratio | 1.00(0.75,2.25) | 1.00(0.71,1.78) | 0.80(0.63,1.57) | 0.75(0.57,1.33) | <0.001 |
| E/e' ratio (septal) | 14(11,20) | 17(12,23) | 15(12,24) | 17(11,23) | 0.183 |
| E/e' ratio (lateral) | 11(8,15) | 12(9,16) | 13(9,17) | 12(8,17) | 0.192 |
| Anterior akinesia or dyskinesia (%) | 43(30,57) | 43(20,50) | 43(29,57) | 40(14,57) | 0.155 |
| MR severity: | |||||
| None or trace | 123(37%) | 110(37%) | 106(38%) | 96(31%) | 0.145 |
| Mild | 149(45%) | 130(44%) | 128(46%) | 147(48%) | 0.456 |
| Moderate | 43(13%) | 47(16%) | 38(14%) | 53(17%) | 0.240 |
| Severe | 14(4%) | 8(3%) | 7(3%) | 10(3%) | 0.460 |
| Coronary anatomy: | |||||
| No of vessels with stenosis ≥ 50% | |||||
| 1 | 46(14%) | 24(8%) | 24(9%) | 18(6%) | <0.001 |
| 2 | 101(31%) | 94(32%) | 87(31%) | 84(27%) | 0.362 |
| 3 | 183(56%) | 177(60%) | 168(60%) | 205(67%) | 0.006 |
| Stenosis of proximal LAD ≥75% | 242(73%) | 200(68%) | 185(66%) | 199(65%) | 0.020 |
| Duke CAD severity index | 52(39,65) | 65(39,77) | 65(39,77) | 65(39,77) | 0.030 |
LVEF – left ventricular ejection fraction, ESVI – end systolicvolumeindexed, EDVI - end diastolic volume indexed, E - early diastolic fillingvelocity, A – atrial contraction induced diastolic filling velocity wave, e' - early diastolic myocardial velocity, MR – mitral regurgitation, LAD – left anterior descending , CAD – coronary artery disease