Table 3.
The rs4880 SOD2 SNP genotype frequencies in adult patients with ALL and association with hepatotoxicity.
| Genotype | Patients N (%) | CC N(%) | CT N(%) | TT N(%) | Chi-square test P value | Fisher Exact test P value (recessive model) |
|---|---|---|---|---|---|---|
| Total N (%) | 190 (100) | 55 (28.9) | 88 (46.3) | 47 (24.7) | ||
| AST grade 3/4 | 42 (22.1) | 16 (38.1) | 21 (50) | 5 (11.9) | 0.069 | 0.18 |
| ALT grade 3/4 | 68 (35.7) | 19 (27.9) | 30 (44.1) | 19 (27.9) | 0.76 | 0.86 |
| Albumin grade 3/4 | 26 (13.7) | 9 (34.6) | 10 (38.4) | 7 (26.9) | 0.69 | 0.49 |
| ALK-phos grade 3/4 | 27 (14.2) | 10 (37) | 9 (33.3) | 8 (29.6) | 0.35 | 0.36 |
| Bilirubin* grade 3/4 | 43 (22.6) | 18 (41.8) | 14 (32.5) | 11 (25.6) | 0.067 | 0.05 |
| Any Hepatotoxicity grade 4/5** | 23 (12.1) | 10 (43.4) | 10 (43.4) | 3 (13) | 0.11 | 0.09 |
| Any Hepatotoxicity grade 3/4/5 | 129 (67.9) | 41 (31.7) | 54 (41.8) | 34 (26.35) | 0.12 | 0.08 |
| Both AST and ALT grade 3 | ||||||
| Or eitherAST or ALT grade 4 | 61(32.1) | 26 (42.6) | 23 (37.7) | 12 (19.6) | 0.018 | 0.006 |
| Or Bilirubin 3/4 |
*
Based on total and direct bilirubin measurements
**
Three patients had hepatic failure of Grade 5.