Figure 3.

Quantification of excitatory synapses on CR+ neurons in DLPFC area 9 for each matched pair of unaffected comparison and schizophrenia subjects^a

^a In panels A-D, the scatter plots indicate the levels of dependent measures (indicated in the heading of each graph) for each unaffected comparison and schizophrenia subject in a pair. Mean (±SD) numbers of sampled CR+ neurons (panel A; schizophrenia: 24.3±6.7, comparison: 24.5±5.9), CR immunoreactivity levels in CR+ cell bodies (panel B; schizophrenia: 6.8×10⁷±2.0×10⁷, comparison: 7.5×10⁷±1.5×10⁷) or surface area of CR+ cell bodies (panel C; schizophrenia: 336±28, comparison: 347±34) did not differ between subject groups. Mean (±SD) density of VGlut1+/PSD95+ puncta on CR+ cell bodies was slightly higher in schizophrenia subjects relative to unaffected comparison subjects (panel D; schizophrenia: 0.0257±0.005, comparison: 0.0236±0.005).