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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Am J Psychiatry. 2016 Jul 22;173(11):1131–1139. doi: 10.1176/appi.ajp.2016.16010025

Figure 4.

Figure 4

Association between the density of excitatory synapses on PV+ neurons and activity-dependent expression levels of PV and GAD67 selectively in schizophrenia subjectsa

a In panels A and B, PV and GAD67 mRNA expression levels are plotted against the density of VGlut1+/PSD95+ puncta on PV+ cell bodies across subjects. The mean density of VGlut1+/PSD95+ puncta on PV+ cell bodies positively predicted the relative mRNA levels of PV (panel A) and GAD67 (panel B) in the schizophrenia subjects and not in the comparison subjects. In panels C and D, somal PV immunoreactivity levels are plotted against the density of VGlut1+/PSD95+ puncta on PV+ cell bodies across subjects or across all sampled PV+ neurons. Across subjects, the mean density of VGlut1+/PSD95+ puncta on PV+ cell bodies positively predicted the mean somal PV immunoreactivity levels in the schizophrenia subjects but not in the comparison subjects (panel C). Across all sampled PV+ neurons (N=725), the density of VGlut1+/PSD95+ puncta on PV+ cell bodies positively predicted somal PV immunoreactivity levels (panel D). Diamonds (blue): unaffected comparison subjects. Crosses (red): schizophrenia subjects. Trendlines (black): regression lines across all subjects.