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. 2016 Apr 15;7(6):824–832. doi: 10.1111/jdi.12516

Figure 5.

Figure 5

Berberine (BBR) dose‐dependently suppresses homocysteine thiolactone (HTL)‐induced oxidative stress and improves cell viabilities in cultured human umbilical vascular endothelial cells (HUVECs). Cultured HUVECs were pretreated with BBR (10, 50, 100 μmol/L) for 1 h and then incubated with HTL (1 mmol/L) for 24 h. (a) Cell viability was measured by methylthiazolyldiphenyl‐tetrazolium bromide. (b) Intracellular reactive oxygen species (ROS) production was detected by dihydroethidium fluorescence. (c) Quantitative analysis of ROS production. All data are expressed as mean ± SE of the mean. Each group n = 3. *P < 0.05 vs control (Con), # P < 0.05 vs HTL alone.