Table 6.
Associations of the genetic variants with prediabetes‐related clinical trials among control participants with body mass index less than 24
| SNP | FPG (mmol/L) | P‐value | HbA1c (%) | P‐value | HOMA‐β | P‐value | HOMA‐IR | P‐value | Systolic pressure (mmHg) | P‐value | Diastolic pressure (mmHg) | P‐value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rs3774261 | ||||||||||||
| AA | 4.81 ± 0.32 | 0.532 | 5.07 ± 0.42 | 0.933 | 113.36 ± 98.32 | 0.956 | 1.41 ± 0.79 | 0.632 | 119.93 ± 16.61 | 0.025 | 78.07 ± 10.26 | 0.043 |
| GA | 4.81 ± 0.29 | 5.06 ± 0.50 | 117.61 ± 112.17 | 1.42 ± 0.81 | 117.61 ± 12.21 | 76.27 ± 8.79 | ||||||
| GG | 4.77 ± 0.29 | 5.08 ± 0.43 | 114.92 ± 70.37 | 1.42 ± 0.79 | 115.77 ± 15.46 | 75.99 ± 9.20 | ||||||
| Rs822393 | ||||||||||||
| CC | 4.83 ± 0.28 | 0.454 | 5.07 ± 0.41 | 0.140 | 103.82 ± 65.22 | 0.574 | 1.45 ± 0.92 | 0.890 | 117.28 ± 12.73 | 0.836 | 76.387 ± 8.33 | 0.659 |
| CT | 4.79 ± 0.32 | 5.02 ± 0.48 | 119.23 ± 128.47 | 1.38 ± 0.70 | 118.72 ± 15.90 | 77.51 ± 9.86 | ||||||
| TT | 4.80 ± 0.30 | 5.16 ± 0.46 | 109.27 ± 63.11 | 1.48 ± 0.82 | 117.51 ± 16.61 | 76.80 ± 9.37 | ||||||
Data presented as mean ± standard deviation. FPG, fasting plasma glucose; HbA1c, glycosylated hemoglobin; HOMA‐β, homeostasis model assessment of beta‐cell function; HOMA‐IR, homeostasis model assessment of insulin resistance; SNP, single nucleotide polymorphism.