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. 2016 Nov 2;10:253. doi: 10.3389/fncel.2016.00253

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Copyright © 2016 Hu, Zou, Huang, Zhang, Lourenco, Chen, Halliday, Wang and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROCK1 levels modulate Aβ secretion. (A,C) Effects of knocking down ROCK1 levels (A) and increasing constitutively activated ROCK1 (ROCK1 CA) levels (C) on secreted Aβ. HEK293 cells were transfected with ROCK1 siRNA (siROCK1), scramble siRNA (siCON), ROCK1 CA plasmid and pcDNA (Con) and 48 h post-transfection secreted Aβ40 was measured by ELISA. (B,D) Representative immunoblot confirms ROCK1 knockdown (B) and increase (D). (E) Cell proliferation assay following ROCK1 CA plasmid transfection. Data are presented as Mean ± SEM. Graphs represent % of control groups, n = 10; students’ t test, ***p < 0.01.