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. 2016 Nov 2;10:253. doi: 10.3389/fncel.2016.00253

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Copyright © 2016 Hu, Zou, Huang, Zhang, Lourenco, Chen, Halliday, Wang and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROCK1 is up-regulated with neuronal autophagosome accumulation in AD mice. (A) Representative ROCK1 (upper panels) and LC3 (lower panels) immunofluorescence in AD and normal mouse brain sections. (B) Representative immunohistochemical (IHC) micrographs of Aβ (6E10, upper panels) and Beclin1 (lower panels) immunofluorescence in AD and normal mouse brain sections. (C) Quantification of ROCK1 immunopositive neurons in AD mouse brain sections compared to control sections (n = 4). (D) Quantification of Beclin1 immunopositive neurons in AD mouse brain sections compared to control sections (n = 4). Data are expressed as mean ± SEM; **p < 0.01, ***p < 0.001.