. 2016 Nov 2;7:1699. doi: 10.3389/fmicb.2016.01699

Table 1.

Incidence of diarrhea and fecal virus shedding in Gn pigs after HuNoV GII.4 challenge^a.

Group	n	Diarrhea^b			Virus shedding^b
		Pigs with diarrhea (%)^∗	Mean days to onset (SEM)^∗∗	Mean duration days (SEM)^∗∗	Pigs shedding virus (%)^∗	Mean days to onset (SEM)^∗∗	Mean duration days (SEM)^∗∗
Cocktail-7d	5	1 (20%)^A	7.0 (1.0)^A	0.2 (0.2)^A	4 (80%)^A	4.0 (1.2)^AB	1.0 (0.3)^AB
Cocktail+1d	5	1 (20%)^A	7.2 (0.8)^A	0.2 (0.2)^A	5 (100%)^A	4.8 (0.2)^AB	1.0 (0)^A
RB-7d	4	3 (75%)^AB	3.3 (1.6)^AB	1.3 (0.5)^AB	3 (75%)^A	6.3 (0.8)^A	1.5 (0.6)^AB
LGG+EcN	5	3 (60%)^AB	4.0 (1.6)^AB	1.8 (1.1)^AB	0^B	8.0 (0)^C	0^C
Control	9	8 (89%)^B	3.9 (0.7)^B	2.2 (0.4)^B	8 (89%)^A	2.8 (0.8)^B	3.2 (0.9)^B

^aGn pigs were inoculated with a HuNoV GII.4 2006b variant 092895 at 33 days of age. Diarrhea and virus shedding were monitored by daily rectal swab sampling and RT-qPCR after inoculation. Calculation included all pigs in each group from PID1 to PID7.

^bIf diarrhea or virus shedding was not observed, the days to onset was recorded as 8 and the duration days was recorded as 0 for statistical purposes.

^∗Fisher’s exact test or ^∗∗Kruskal–Wallis test was used for comparisons. Different letters indicate significant differences among treatment groups (P < 0.05), while shared letters indicate no significant difference.