Fig. 4.

Examples of patients treated with T-VEC with a DR without PPR. a Patient without PPR and DR onset ≤6 months. The patient had recurrent stage IIIC melanoma with multiple in-transit tumor lesions on the leg. All lesions were injected with T-VEC and all resolved (CR) by 37 weeks after the start of treatment. The patient remained in CR until the end of the study, with DR duration of 60 weeks. b Patient without PPR and measurable response onset >6 months. The patient had recurrent stage IIIB (in-transit) melanoma of the scalp with 20 cutaneous lesions that were injected with T-VEC. Partial response was recorded on week 30 after the start of treatment. Lesions resolved completely by week 38 and the patient remained in CR until the end of the study, with DR duration of 48 weeks. Responses are reported per External Assessment Committee. Titles above each photography are weeks on study. DR durable response, PRR progression prior to response, CR complete response